Associate Director, PBPK Clinical Pharmacology

Posted 4 days ago
Main Location
New York City, NY, United States
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At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

PBPK modeling has become an important component of clinical development.  PBPK models are used to characterize the drug absorption, distribution, metabolism, and excretion (ADME) properties based on calibration to non-clinical and clinical data.  This enables extrapolation and generation of hypotheses to inform clinical development.  Additional applications include drug-drug interaction (DDI) risk assessment, PK and dose predictions in humans and special populations, prediction of target tissue concentrations, and formulation optimization.  The responsibilities of the PBPK Scientist will include:

  • Providing leadership to and collaboration with multidisciplinary project teams to develop and apply PBPK models
  • Demonstrate high proficiency in the development and application of PBPK models to address drug-discovery and development questions
  • Partnering with external groups to accelerate the internal PBPK efforts in key disease areas
  • Independently provide expert support to project teams to design, execute and interpret clinical pharmacology studies
  • Independently develop appropriate PBPK tools to support innovative applications
  • Network with stakeholders in non-clinical DMPK, Biotransformation, and pharmaceutical development to identify and interpret experiments critical for model development and refinement
  • Align PBPK model deliverables with the clinical pharmacology and clinical development plans
  • Stay informed with emerging literature and science in the DMPK and PBPK fields
  • Build and maintain a personal track record of publication in the area of PBPK
  • Contribute to the standards of practice within the department
  • Participate and contribute to departmental and R&D initiatives
  • Begin to learn how to align disease area PBPK strategy with organizational priorities
  • Establish and maintain effective collaborations with stakeholders in other functional areas
  • Serve as a subject matter expert to both internal colleagues and the external scientific DMPK/CP&P community
  • Maintains an active relationship with colleagues in Clinical Pharmacology & Pharmacometrics at the project level as well as in the advancement of Pharmacometrics

Requirements:

  • Ph.D. in DMPK, pharmaceutics, clinical pharmacology, engineering, toxicology or a related field.  M.S. in appropriate field with significantly more experience may be considered.  In addition to the Ph.D., 5+ years of pharmaceutical industry experience in applying PBPK modeling for DDI and PK predictions for Associate Director level.  Candidates with less education and experience may be considered for a lower starting level commensurate with education and experience.
  • Excellent understanding of the theory and principles in pharmacokinetics and pharmacodynamics, drug metabolism and transporters
  • Understanding of the theory, principles and statistical aspects of mathematical modeling and simulation
  • Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop PBPK models
  • Ability to communicate internally and externally on topics related to Clinical Pharmacology and PBPK is required
  • Ability to keep up to date with and propose the implementation of scientific and technological developments in the area of PBPK
  • Hands-on experience with one or more of the modeling software like Simcyp, GastroPlus, PKSim, etc.
  • Experience with general programming and data analysis tools/languages such as R, Matlab, Spotfire, etc, is desirable
  • Desire to interact as a modeling and simulation expert with matrix project teams working closely with experts from different functional areas (pre-clinical and clinical)
  • Knowledge of current practices and issues in pharmaceutical R&D in disciplines such as clinical pharmacology

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. 


Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

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Associate Director, PBPK Clinical Pharmacology
Bristol Myers Squibb