Senior/Staff Research Scientist - Genomics

Main Location
San Carlos, CA, United States
Open jobs

It’s our mission to empower every person to improve their life through DNA. We believe DNA will be digitally accessible to each person so that it can be used—at any time—to improve health outcomes and accelerate research.

Helix powers life-changing population health programs. Our world-class clinical laboratory platform and proprietary Exome+ assay enable health systems to integrate genomic information into routine clinical care and enhance the accessibility of personalized healthcare. Additionally, Helix stores and protects participants’ DNA information, so that as the science evolves, health systems, patients and researchers are able to continuously benefit from a lifetime of DNA insights. 

Our big vision comes with big responsibility. That’s why we’re building a diverse team of experts in the field of genetics, engineering, design, business development, and beyond to help bring actionable insights to our customers.

The mission of the Helix Research team is to conduct cutting-edge genomics research, to collaborate with and support our clinical, health, and life science partners in population-based genomic studies, by demonstrating the capabilities of the Helix Exome+ platform and suite of bioinformatics products and services.  We are also responsible for the integration, analysis, and interpretation of genomic, phenotypic, and clinical information obtained from EMRs, self-reported health outcomes, claims, quantitative biomarkers, and other digital phenotypes. We believe that everyone will be sequenced as part of routine medical care in the not-too-distant future and our fast and nimble team helps generate the evidence to turn that faith into fact.  

As a Senior/Staff Research Scientist, you will:

  • Conduct short- and long-term research projects, varied in scale, algorithmic and data complexity, phenotype, disease, and therapeutic area
  • Implement creative solutions to research problems, and be eager to learn and apply cutting-edge tools to questions.
  • Work collaboratively with internal and external teams to conduct research on genomic and phenotypic data to replicate published studies in new cohorts and discover novel associations
  • Present your findings internally to key stakeholders and externally to partners and at conferences

Required background:

  • A PhD in bioinformatics, computer science, computational biology, genomics, or a related field with 5+ years of experience
  • Experience with GWAS and PheWAS of using large human genomic datasets, such as 1000Genomes, UKBiobank, TOPmed, MVP, etc.
  • Experience with open-source bioinformatics tools / packages (Hail, PLINK, Bioconductor, GATK, etc)
  • Candidates should possess outstanding communication skills as well as broad biological interests that will enable them to facilitate interactions between clinicians, bioinformaticians, scientists, and business and learn new areas easily.
  • Strong programming and scripting abilities in languages (Python, R, etc).

The ideal candidate will have:

  • Post-doc experience and strong publication record
  • Prior experience with large observational databases (e.g., administrative claims and electronic medical records, disease registries, etc.) and observational research/epidemiology statistical methods
  • Working knowledge of OMOP and/or other CDM
  • Experience working with cloud-based analytical platforms (AWS, etc)
  • Experience in writing queries for SQL and document databases

What Helix has to offer you:

Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits:

  • Competitive compensation, including meaningful equity
  • Health insurance, including medical, dental, and vision
  • 12 weeks of Maternity or Paternity leave
  • 4 weeks of paid Pregnancy Disability
  • 401(k) with employer matching
  • On-premise nursing room
  • Commuter benefits
  • Catered meals
  • Flexible PTO

Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws.

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Senior/Staff Research Scientist - Genomics