Scientist II – mRNA Platform Development

About AbbVieAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.
 

The Discovery Research mRNA-tLNP department is seeking a driven and collaborative Research Scientist to join our dynamic mRNA group. Our team partners with multidisciplinary groups across AbbVie to develop therapeutic solutions for diverse disease areas, including immunology, oncology, and neurology.

As a key member of the mRNA team, you will independently lead mRNA production efforts with the support of other team members, contribute to RNA platform innovation, and deliver high-quality mRNA drug substances for various therapeutic applications. You will collaborate closely with scientists from multiple functional areas and therapeutic teams, manage both internal and external partnerships, and actively contribute to the advancement of AbbVie’s mRNA capabilities.

Key Responsibilities:

• Develop and optimize mRNA purification processes using a variety of chromatography techniques on ÄKTA systems.
• Perform in vitro transcription (IVT), purification, and characterization of mRNA to produce therapeutic-grade materials for in vitro and in vivo studies.
• Establish high-throughput IVT and purification methods using liquid handling systems.
• Evaluate and integrate emerging technologies to enhance the RNA platform in support of cross-functional research initiatives.
• Communicate research progress through presentations and written reports to both scientific and non-scientific audiences, internally and externally.
• Supervise, mentor, and share expertise with colleagues across functions and project teams.
• Contribute to the preparation of publications, reports, and external presentations.

• BS with 7+ years, or MS with 5+ years, in biochemistry, molecular biology, or a related field, preferably with 1-3 years of direct mRNA therapy experience.
• Proficient in RNA in vitro transcription and chromatography-based RNA purification (ÄKTA systems experience preferred).
• Strong knowledge of other RNA formats (e.g., circular RNA, self-amplifying RNA) and their purification/characterization challenges.
• Familiar with implementation of liquid handling automation in laboratory workflows.
• Excellent documentation, organizational, and communication skills.
• Demonstrated ability to work independently and collaboratively in a fast-paced, team-oriented environment with strong problem-solving skills and a resilient mindset.

Key Competencies:

• Builds strong relationships with peers and cross functionally with partners to enable higher performance.
• Learns fast, grasps the "essence" and can change course quickly where indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.
• Strong interpersonal and communication skills with proven ability to work within a team environment.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

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